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Lisinopril vs enalapril dosage (and placebo) N=13 Primary Purpose: Treatment new zealand drug store online Effect of diclofenac on renal function tests in the first 1, 6, and 12 months effect on renal function tests in the first 1, 6, and 12 months Primary outcome measures Urinary CML/MG excretion (and enalapril vs placebo): MG excretion: Intervention/Control: Treatment with 2.5mg of diclofenac in two divided doses with or without enalapril and at doses of 15mg 30mg, every other day and at doses of 15mg 30mg, every other day n=17 Primary Purpose: Treatment Difference in MG excretion between diclofenac versus enalapril (P values less than 0.05 for difference in MG excretion) at each dose (2.5-15mg vs 30mg) in a population with an estimated baseline renal function (urinary creatinine clearance) of 100 ml/min/kg concentrations of MG excretion relative to values obtained 3 days earlier from healthy volunteers (n=11) taking a placebo (no medication) between diclofenac versus enalapril (P values less than 0.05 for difference in MG excretion) (2.5-15mg vs 30mg) at each dose (2.5-15mg vs 30mg) in a population with an estimated baseline renal function (urinary creatinine clearance) of 100 ml/min/kg Interventional Phase 3 Janssen Research & Development, Inc. Industry Allocation: Randomized Intervention Model: Parallel Assignment Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor) Primary Purpose: Treatment Change in the urinary excretion of glomerular filtration rate (GFR), as measured by modified counting time (MTCT) Change in the rate of excretion creatinine Hydrochlorothiazide brand australia from renal disease (as a surrogate measure of renal function) Change in the rate of urinary urea nitrogen (and enalapril vs placebo) from baseline to the final month of treatment (and 10 more...) 20 All 18 Years and older (Adult, Adult) NCT02408716 IRB00171328 February 2016 January 2017 March 3, June 29, 2016 Johns Hopkins University Hospitals Baltimore, Maryland, United States 39 NCT03624072 Completed Has Results Effect of diclofenac and Enalapril on Hemodynamic Events in Severe Metabolic Diseases Disease Kidney Disease Drug: diclofenac Other: placebo Interventional Masking: Triple (Participant, Investigator, Outcomes Assessor) Primary Purpose: Prevention Percentage Change From Baseline In Renal Glomerular Filtration Rate (RFFR) Between Groups Percentage Change From Baseline In Hemodynamics Between Groups Percentage Change From Baseline In Blood Urea Nitrogen Level Between Groups (and 29 more...) 10 All 18 Years to 80 (Adult, Peut on acheter de la ventoline sans ordonnance Older Adult) NCT03624072 IRB00171418 February 2016 November 8, Johns Hopkins Hospital 40 NCT03176747 Recruiting Diclofenac for Severe Hepatic Enzyme Inflammation and Hepatocellular Carcinoma Drug: diclofenac Drug: Placebo Interventional Primary Purpose: Treatment Incidence of Treatment-Emergent Adverse Events as lisinopril oral liquid Reaction Profiles by Baseline and At Month 3 Incidence of Treatment-Emergent Adverse Events as Reaction Profiles by Baseline and At Month 3 Response Percentage Change From Baseline In Renal Glomerular Filtration Rate (RFFR) between Groups (and 9 more...) 14 All 18 Years and older (Adult, Adult) NCT03176747 IRB00171439 February 2017 April 2018 15, Johns Hopkins Hospital Baltimore, Maryland, United States National Institutes of Health Clinical Center Bethesda, Maryland, United States

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